Warring Villains Gather To Destroy Each Other Once And For All in Ultimate Spider-Man #21

By Chad Burdette

 on September 22, 2025

It’s been one trial after another for the Parker family. While Peter was trapped in the Savage Land with Harry Osborn, Richard and the Stark nanosuit worked to continue on Spider-Man’s crime fighting.

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That led to a meeting of the new Spidey and Black Cat, bonding over the legacies of their fathers. Back in the Savage Land, a brutal chase with Kraven and help from Mysterio allowed Peter to escape with the knowledge his entire family is in danger. Now guess who’s coming to dinner in Ultimate Spider-Man #21

Comic Watch Review:

• Ultimate Spider-Man #15: ‘’Cause I understand you’ve been running from the man/That goes by the name of the Sandman’
• Ultimate Spider-Man #16: The Ghosts of Gwen Stacy
• Ultimate Spider-Man #19; Tooth & Nail
• Ultimate Spider-Man #20: A Table with Glasses

Ultimate Titles Also Out This Week

• Ultimate Hawkeye Sets Their Sights And Arrows On The Maker in ULTIMATE HAWKEYE #1

Other Spider-Family Titles Also Out This Week

• Spider-Girl Must Decide What Kind Of Superhuman She Wants To Be in Spider-Girl #4
• The Mystery Deepens As The Threat Increases… But What Is This Mysterious Force’s Endgame in Spider-Man & Wolverine #5
• Black Cat #2
• All-New Spider-Gwen: Ghost-Spider #2

Francesco Manna Variant Cover:

David Messina Variant Cover:

Alexander Lozano 1:25 Incentive Variant Cover:

Ultimate Spider-Man # 21

Blood boils over as these warring villains gather to destroy each other once and for all… or will they reunite against their common enemy, Spider-Man?

Creative Team

• Writer: Jonathan Hickman
• Artist: David Messina
• Colorist: Matthew Wilson
• Letterer: VC’s Cory Petit
• Cover Artist: Marco Checchetto & Matthew Wilson
• Variant Cover Artists: Francesco Manna; Alexander Lozano; David Messina
• Editor: Wil Moss
• Assistant Editor: Michelle Marchese
• Format: Ongoing
• Cover Price/Page Count: $4.99/32 pages

Warring villains gather to destroy each other once and for all in Ultimate Spider-Man #21, on shelves and digital platforms September 24, 2025, from Marvel Comics