Aunt May Drops Some Wisdom That You Won't Forget Anytime Soon in The Amazing Spider-Man #16

By Chad Burdette

on November 18, 2025

Readers of Joe Kelly, Pepe Larraz and John Romita Jr.’s current run of AMAZING SPIDER-MAN are getting a double dose of wall crawler action!

Following his brutal defeat at the hands of new supervillain Hellgate, there are TWO Spider-Men?! One Spider-Man has gone cosmic! Expect new villains, new allies, a new suit and possibly a new girlfriend (?!) as Spidey enters his intergalactic era! Meanwhile, the other Spider-Man is swinging around New York City—dishing out justice in a very unfriendly manner.

But is Spidey ready for Tombstone’s ally PLAGUE RX?! This terrifying new villain’s novel power will punish Spider-Man in ways he’s never been punished before!

The mystery heats up as the title approaches its milestone 1000th issue next year.

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David Marquez Variant Cover:

Marco Forcelloni Pixar Toy Story Homage Variant Cover:

Simone Di Meo From the Chaos a Costume Variant Cover:

Giuseppe Camuncoli 1:25 Incentive Variant Cover:

Lee Bermejo Amazing Visions Variant Cover/1:100 Incentive Virgin Variant Cover:

The Amazing Spider-Man #16

Part of being Spider-Man is facing horrific scientifically wondrous SPIDER-SLAYERS!

This new Spider-Slayer is particularly dangerous and endangers not only Spider-Man but the new teen hero KINTSUGI!

Creative Team

Writer: Joe Kelly
Artist (Penciller): John Romita Jr.
Inker: Scott Hanna
Colorists: Marcio Menyz
Letterer: Joe Caramagna
Cover Artists: John Romita Jr, Scott Hanna, and Marcio Menyz
Variant Cover Artist: David Marquez; Lee Bermejo; Marco Forcelloni; Simone Di Meo; Giuseppe Camuncoli
Editor: Nick Lowe
Assistant Editor: Kaitlyn Lindvedt
Associate Editor: Tom Groneman
Cover Price/Page Count: $5.99/40 Pages

Aunt May drops some wisdom that you won’t forget anytime soon in The Amazing Spider-Man #16 on shelves and digital platofrms November 19, 2025, from Marvel Comics